About Episteme Prognostics, Inc.

Episteme Prognostics, Inc. was founded in 2021 as a spin-out from Memorial Sloan Kettering Cancer Center (MSKCC) and Dartmouth Cancer Center.

Our founders, Surajit Dhara, PhD, and Steven D. Leach, MD, identified a tumor-cell-intrinsic gene regulatory pattern in pancreatic cancer strongly associated with chemotherapy response. This discovery opened a new approach to understanding how cancer cells respond to treatment and potentially develop resistance.

We began with pancreatic cancer, one of the most aggressive malignancies with extremely limited precision medicine options. These early findings became the foundation of Episteme’s scientific mission.

Today, we are advancing PancEpistemeDx™, our first diagnostic, while building a platform with broad potential across cancer therapies and biopharma development.

Founders & Leadership

Surajit Dhara, PhD

Dr. Dhara is the Chief Executive Officer and Co-Founder of Episteme Prognostics, is a renowned cancer biologist, best known for his invention of ATAC-array technology, which led to the founding of Episteme Prognostics. Before founding Episteme, Dr. Dhara led research teams in pancreatic cancer epigenetic clinical biomarker discovery, providing cross-functional team leadership and fostering multidisciplinary collaborations at MSKCC, Dartmouth Cancer Center, and NYU Langone Medical Center. He holds several patents, has numerous publications in high-impact journals, and has contributed chapters to academic books. Dr. Dhara graduated from All India Institute of Medical Sciences, New Delhi, India, and completed his Postdoctoral Fellowship at Johns Hopkins University, MD, USA.

Steven D. Leach, MD

Dr. Leach, Co-Founder, and Chair of the Scientific Advisory Board of Episteme, is a world-renowned surgical oncologist and pancreatic cancer researcher, currently leading Dartmouth Cancer Center, a joint enterprise of the Geisel School of Medicine at Dartmouth and Dartmouth Health. He serves as a professor across multiple departments within Geisel and Dartmouth’s Guarini School of Graduate and Advanced Studies. Dr. Leach previously held the David M. Rubenstein Chair and was the inaugural director of the Rubenstein Center for Pancreatic Research. Before Dartmouth, he spent 14 years at Johns Hopkins University as the Paul K. Neumann Professor in Pancreatic Cancer, Chief of the Division of Surgical Oncology, and Vice-Chair of Academic Affairs in the Department of Surgery. His numerous accolades include being named a Fellow of the American Academy for the Advancement of Science in 2018 and election to the National Academy of Medicine in 2023. Dr. Leach has also chaired the Pancreatic Cancer Action Network’s Scientific and Medical Advisory Board and served on the Princeton University Board of Trustees. He holds an undergraduate degree from Princeton University and a medical degree from Emory University, with a residency at Yale University, where he was Chief Resident in General Surgery and completed a research fellowship in Surgery and Cell Biology, followed by a surgical oncology fellowship at MD Anderson Cancer Center.

Board of Directors

Surajit Dhara, PhD

Surajit Dhara, PhD

Co-Founder, President,
CEO, Board Member

Gregory P. Ho, JD

Gregory P. Ho, JD

Board Member

Jason Rifkin, JD, MB

Jason Rifkin, JD, MB

Board Member

Research & Development Team

Louis Sussman, MD

Louis Sussman, MD

Director
CLIA Diagnostic Laboratory

Feras Hantash, PhD

Feras Hantash, PhD

Assistant Director
CLIA Diagnostic Laboratory

Arturo Orlacchio, PhD

Arturo Orlacchio, PhD

Senior Vice President, Research and Development

Miriam Fayad, ASCP

Miriam Fayad, ASCP

Senior Immunohistochemistry Technologist

Sharon James, MBA, CLT

Sharon James, MBA, CLT

General Supervisor
CLIA Diagnostic Laboratory

Scientific Advisory Board

Steven D. Leach, MD

Steven D. Leach, MD

Chair, Scientific Advisory Board
Interim Dean, Geisel School of Medicine at Dartmouth

Christine Iacobuzio-Donahue, MD, PhD

Christine Iacobuzio-Donahue, MD, PhD

Director, David M. Rubenstein Center for Pancreatic Cancer Research
Memorial Sloan Kettering Cancer Center (MSKCC)

Christina S. Leslie, PhD

Christina S. Leslie, PhD

Professor, Computational and Systems Biology Program
Memorial Sloan Kettering Cancer Center (MSKCC)

Georg Werner Feldmann, MD

Georg Werner Feldmann, MD

Professor, Department of Internal Medicine
Rheinische Friedrich-Wilhelms-Universität Bonn

Michael J. Yunes, MD

Michael J. Yunes, MD

Chief, Division of Radiology/Oncology UMass Chan Medical School